含受损嘌呤位点的 DNA 糖基酶识别与结合
中文名称
通路描述
DNA 糖基酶识别并结合含受损嘌呤的位点。DNA 糖基酶对受损碱基的识别和移除被认为涉及酶沿着 DNA 分子的小沟扩散。酶可能在损伤位点压缩受损 DNA 的骨架。这种压缩被认为会导致受损残基向外旋转，进入酶的一个“口袋”，该口袋负责识别并断裂与骨架结合的受损碱基（Slupphaug 等 1996, Parikh 等 1998）。
英文描述
Recognition and association of DNA glycosylase with site containing an affected purine The recognition and removal of an altered base by a DNA glycosylase is thought to involve the diffusion of the enzyme along the minor grove of the DNA molecule. The enzyme presumably compresses the backbone of the affected DNA strand at the site of damage. This compression is thought to result in an outward rotation of the damaged residue into a "pocket" of the enzyme that recognizes and cleaves the altered base from the backbone (Slupphaug et al. 1996, Parikh et al. 1998).
所含基因
36 个基因