POLB 依赖性长补丁碱基切除修复
中文名称
通路描述
在 POLB 依赖性长补丁碱基切除修复（BER）过程中，PARP1 和/或 PARP2 被招募到 BER 位点，同时招募 flap endonuclease FEN1。PARP1 和/或 PARP2 和 FEN1 促进由 POLB 介导的链置换合成，该合成涉及在 APEX1 创建的单链断裂（SSB）的 3' 端掺入 2-10 个核苷酸。当 DNA 链置换合成完成并断裂置换出的链后，POLB 招募 DNA 连接酶 I（LIG1）来连接 SSB（Klungland 和 Lindahl 1997, Dimitriadis 等 1998, Prasad 等 2001, Lavrik 等 2001, Tomkinson 等 2001, Ranalli 等 2002, Cistulli 等 2004, Liu 等 2005）。
英文描述
POLB-Dependent Long Patch Base Excision Repair During POLB-dependent long patch base excision repair (BER), PARP1 and/or PARP2 is recruited to the BER site along with flap endonuclease FEN1. PARP1 and/or PARP2 and FEN1 facilitate POLB-mediated strand displacement synthesis which involves incorporation of 2-10 nucleotides at the 3' end of the APEX1-created single strand break (SSB). After the DNA strand displacement synthesis is completed and the displaced strand is cleaved, POLB recruits DNA ligase I (LIG1) to ligate the SSB (Klungland and Lindahl 1997, Dimitriadis et al. 1998, Prasad et al. 2001, Lavrik et al. 2001, Tomkinson et al. 2001, Ranalli et al. 2002, Cistulli et al. 2004, Liu et al. 2005).
所含基因
9 个基因