BIM激活并转位至线粒体
中文名称
通路描述
BIM作为细胞骨架完整性的哨兵发挥作用。它作为两种变体蛋白存在：BIM-EL和BIM-L。在健康细胞中，这两种异构体通过微管上的驱动蛋白轻链DLC1被募集到驱动蛋白马达复合物中。JNK或MAPK8通过磷酸化在紫外线照射下释放BIM。
英文描述
Activation of BIM and translocation to mitochondria BIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor complex on microtubules via the dynein light chain DLC1. JNK or MAPK8 releases BIM in response to UV irradiation by phosphorylation.
所含基因
3 个基因