CaMK IV 介导的 CREB 磷酸化
中文名称
通路描述
Ca2+-钙调蛋白依赖性蛋白激酶（CaM 激酶）级联包括三种激酶：CaM 激酶激酶（CaMKK）；以及 CaM 激酶 CaMKI 和 CaMKIV，它们被 CaMKK 磷酸化和激活。该级联的成员对细胞内 Ca2+ 水平的升高作出反应。CaMKK 和 CaMKIV 在细胞核和细胞质中定位，而 CaMKI 仅在细胞质中。核 CaMKIV 通过磷酸化几种转录因子调节转录，包括 CREB。在细胞质中，CaMKK、CaMKIV 和其他信号级联（包括涉及 cAMP 依赖性激酶（PKA）、MAP 激酶和蛋白激酶 B（PKB/Akt）的级联）之间存在广泛的交叉对话。
英文描述
CaMK IV-mediated phosphorylation of CREB The Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade includes three kinases: CaM-kinase kinase (CaMKK); and the CaM kinases CaMKI and CaMKIV, which are phosphorylated and activated by CaMKK. Members of this cascade respond to elevation of intracellular Ca2+ levels. CaMKK and CaMKIV localize both to the nucleus and to the cytoplasm, whereas CaMKI is only cytosolic. Nuclear CaMKIV regulates transcription through phosphorylation of several transcription factors, including CREB. In the cytoplasm, there is extensive cross-talk between CaMKK, CaMKIV and other signaling cascades, including those that involve the cAMP-dependent kinase (PKA), MAP kinases and protein kinase B (PKB/Akt).
所含基因
10 个基因