Cam-PDE 1 激活
中文名称
通路描述
钙调蛋白（calmodulin）在钙离子（Ca2+）存在下与钙调蛋白依赖性磷酸二酯酶 PDE1 结合，激活 PDE1。PDE1 有三种亚型：PDE1A、PDE1B 和 PDE1C，它们的作用是水解环磷酸鸟苷（cGMP）和环磷酸腺苷（cAMP）。它们的作用是拮抗腺苷酸环化酶酶合成的增加的内源性第二信使浓度，从而调节细胞内 cAMP 动力学，以应对细胞质 Ca2+ 浓度的变化。PDE1 主要位于细胞质中，但不同的亚型在不同组织中表达。
英文描述
Cam-PDE 1 activation Human Ca2+/calmodulin-dependent phosphodiesterase PDE1 is activated by the binding of calmodulin in the presence of Ca(2+). PDE1 has three subtypes PDE1A, PDE1B and PDE1C and their role is to hydrolyze both cGMP and cAMP. Their role is to antagonize the increased concentration of the intracellular second messengers determined by the synthetic activity of the adenylate cyclase enzymes thus governing intracellular cAMP dynamics in response to changes in the cytosolic Ca2+ concentration. PDE1 are mainly cytosolic but different isoforms are expressed in different tissues.
所含基因
4 个基因