磷酸 -PLA2 通路
中文名称
通路描述
磷脂酶 A2（PLA2）酶从磷脂的 sn-2 位点水解花生四烯酸（AA）。AA 是二十烷酸的前体，是参与炎症反应的脂质介质。PLA2 酶作为磷脂酰基周转的调节者发挥作用，既作为膜修复的“管家”，也作为产生炎症脂质介质的产物。PLA2 酶有多种形式，包括分泌型（sPLA2）、钙独立型和细胞质型（cPLA2）。这里注释了介导花生四烯酸释放的 cPLA2 形式。
英文描述
phospho-PLA2 pathway Phospholipase A2 (PLA2) enzymes hydrolyze arachidonic acid (AA) from the sn-2 position of phospholipids. AA is a precursor of eicosanoids, lipid mediators involved in inflammtory responses. PLA2 enzymes function as regulators of phospholipid acyl turnover, either as housekeepers for membrane repair or for the production of imflammatory lipid mediators. There are diverse forms of PLA2 enyzmes including secretory (sPLA2), calcium-independent and cytosolic (cPLA2). The cPLA2 form which mediates arachidonic acid release is annotated here.
所含基因
2 个基因