钙调蛋白通路
中文名称
通路描述
钙调蛋白（CaM）是一种含有四个 EF 手性口袋的小酸性蛋白，每个口袋可以结合一个钙离子，因此它可以结合多达四个钙离子。该蛋白具有两个近似对称的域，中间由一个柔性铰链区域隔开。钙调蛋白是 EF 手性蛋白家族的典型代表。细胞内 Ca2+ 浓度的变化通过三种方式调节钙调蛋白：首先，通过指导其亚细胞分布；其次，促进与不同靶蛋白的结合；第三，通过调节钙调蛋白的各种构象状态，从而产生靶蛋白特异性激活。钙调蛋白结合并激活几种效应蛋白（例如钙调蛋白依赖性腺苷酸环化酶、磷酸二酯酶、蛋白激酶和蛋白磷酸酶钙调激酶）。
英文描述
CaM pathway Calmodulin (CaM) is a small acidic protein that contains four EF-hand motifs, each of which can bind a calcium ion, therefore it can bind up to four calcium ions. The protein has two approximately symmetrical domains, separated by a flexible hinge region. Calmodulin is the prototypical example of the EF-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, by directing its subcellular distribution. Second, by promoting association with different target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. Calmodulin binds and activates several effector protein (e.g. the CaM-dependent adenylyl cyclases, phosphodiesterases, protein kinases and the protein phosphatase calcineurin).
所含基因
1 个基因