ALKBH2 介导的烷基化损伤逆转
中文名称
通路描述
AlkB 是一种 E.coli α-酮戊二酸和 Fe(II) 依赖的二氧酶，氧化相关甲基并释放它们为甲醛。人类 AlkB 的两个同源物 ALKBH2 和 ALKBH3 均从甲基化多核苷酸中去除 1-甲基腺嘌呤（1-meA）和 3-甲基胞嘧啶（3-meC），反应依赖于 α-酮戊二酸。它们通过直接损伤逆转起作用，恢复未取代的碱基。E.coli AlkB 和人类 ALKBH2 和 ALKBH3 还可以修复 DNA 中的 1-乙基腺嘌呤（1-etA）残基，同时释放乙醛（Duncan et al., 2002, Lee et al. 2005）。
英文描述
ALKBH2 mediated reversal of alkylation damage AlkB is an E.coli alpha-ketoglutarate- and Fe(II)-dependent dioxygenase that oxidizes the relevant methyl groups and releases them as formaldehyde. Two human homologs of AlkB, ALKBH2 and ALKBH3, both remove 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction. They act by direct damage reversal with the regeneration of the unsubstituted bases. E.coli AlkB and human ALKBH2 and ALKBH3 can also repair 1-ethyladenine (1-etA) residues in DNA with the release of acetaldehyde (Duncan et al., 2002, Lee et al. 2005).
所含基因
1 个基因