E2F 介导的提前复制复合体形成的抑制
中文名称
通路描述
在特定条件下，有丝分裂周期蛋白 B（Cyclin B）可以抑制提前复制复合体的功能。E2F1 激活 Cdc25A 蛋白，以正调控 Cyclin B。Cyclin B/Cdk1 功能恢复，从而导致提前复制复合体的破坏。这一现象已在果蝇中由 Bosco 等人（2001）证明。
英文描述
E2F-enabled inhibition of pre-replication complex formation Under specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk1 function is restored which leads to the disruption of pre-replicative complex. This phenomenon has been demonstrated by Bosco et al (2001) in Drosophila.
所含基因
9 个基因