PIP2 水解的影响
中文名称
通路描述
磷脂酰肌醇二磷酸（PIP2）由磷脂酶 C（PLC）水解产生二酰甘油（DAG）和肌醇三磷酸（IP3）。两者都是强效的第二信使。IP3 扩散到细胞质中，但作为疏水性脂质，DAG 留在细胞膜内。IP3 刺激平滑内质网释放钙离子，而 DAG 激活传统的和不寻常的蛋白激酶 C（PKC）同工酶，促进 PKC 从细胞质向细胞膜的转位。DAG 的作用被肿瘤促进的雄黄酯模拟。DAG 也是前列腺素、内源性大麻素 2-花生四烯酰甘油和 TRP-C（瞬态受体电位经典）阳离子通道亚家族 3、6 和 7 的激活剂的生物合成前体。
英文描述
Effects of PIP2 hydrolysis Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.
所含基因
22 个基因