SNARE 形成的解偶联
中文名称
通路描述
SNARE（SNAp REceptor）蛋白家族是膜融合所需的机器中的关键组分（Söllner et al. 1993, Wu et al. 2017）。SNARE 可分为三大亚族：突触囊泡相关蛋白（SNAPs）、囊泡相关膜蛋白（VAMPs）和syntaxins。SNAPs 含有两个 SNARE 基序，缺乏跨膜域，而是通过硫酯键连接的酰基锚定在膜上（Hong 2005）。VAMPs 或 R-SNAREs 分为两个亚族：短 VAMPs 或 brevins 和长 VAMPs 或 longins。Syntaxins 进化上保守性较差，但除了 STX11 外都是跨膜蛋白（Hong 2005）。包括 Syntaxin-2（STX2）、STX4、STX11 和囊泡相关膜蛋白 8（VAMP8）在内的几种 SNARE 蛋白被认为参与血小板颗粒分泌（Golebiewska et al. 2013）
英文描述
Disinhibition of SNARE formation The SNARE (SNAp REceptor) family of proteins are critical components of the machinery required for membrane fusion (Söllner et al. 1993, Wu et al. 2017). SNAREs can be grouped into three broad subfamilies: synaptosomal-associated proteins (SNAPs), vesicle-associated membrane proteins (VAMPs) and syntaxins. SNAPs contain two SNARE motifs and lack transmembrane domains, instead they are anchored to the membrane by thioester-linked acyl groups (Hong 2005). VAMPS or R-SNAREs have two subfamilies: short VAMPs or brevins and long VAMPs or longins. Syntaxins are evolutionarily less-well conserved, but except STX11 are transmembrane proteins (Hong 2005). Several SNARE proteins including Syntaxin-2 (STX2), STX4, STX11 and Vesicle-associated membrane protein 8 (VAMP8) are thought to be involved in platelet granule secretion (Golebiewska et al. 2013).
所含基因
5 个基因