巨噬细胞产生的活性氧耐受性
中文名称
通路描述
Mycobacteria 中 AhpC 的表达与毒力无关；相反，Mtb 中最重要的是抗氧化系统，包括脂质细胞壁、超氧化物歧化酶（SodB/SodC）和过氧化氢酶/过氧化物酶（KatG）。与作用于硝化应激和铁 sequestration 的酶系统一起，这些似乎对于抵御巨噬细胞产生 ROS/RNS 至关重要，并使细菌能够在吞噬体中持续存在（Zahrt & Deretic 2002）。
英文描述
Tolerance of reactive oxygen produced by macrophages The expression of AhpC in Mycobacteria does not correlate with virulence; instead, the most important parts of the antioxidant system in Mtb appear to be the lipid cell wall, the enzymes SodB/SodC (superoxide dismutases), and the catalase/peroxidase KatG. Together with the enzyme system that acts on nitrosative stress and the sequestration of iron, these appear to be critical in defending against the macrophage's production of ROS/RNS, and enable the bacterium to exist in the phagosome for extended periods (Zahrt & Deretic 2002).
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