RHOBTB3 ATPase 循环
中文名称
通路描述
RHOBTB3 属于 Ras 超家族成员，在进化上与包括 Rho、Miro、Ras、Ran、Arf 和 Rab 在内的其他 Ras 超家族成员不同。由于与 RHOBTB1 和 RHOBTB2 的相似性，RHOBTB3 有时被归类为 RHO GTP 家族的不典型成员。然而，RHOBTB3 的 GTP 结构域与其他 Ras 超家族成员不同，并表现出 ATP 酶活性。除了 GTP 结构域外，RHOBTB3 还包含其他保守结构域。N 端 GTP 结构域后紧跟一个富含脯氨酸的区域，随后是两个 BTB 结构域（广域复合物、轨道、Brca 结构域）的串联，以及一个保守的 C 端 BACK（BTB 和 C 端 Kelch）结构域。与 RHOBTB1 和 RHOBTB2 不同，RHOBTB3 含有 CAAX 盒（前缀化结构域）结构域。RHOBTB 蛋白可形成同源和异源二聚体，但二聚化在 RHOBTB 功能中的作用尚不清楚。RHOBTB3 广泛表达，在胎盘、睾丸、胰腺、肾上腺和唾液腺以及神经和心脏组织中水平较高。RHOBTB3 参与 CUL3 依赖性蛋白泛素化。RHOBTB3 参与从内体到高尔基体的逆行运输。RHOBTB3 参与细胞周期调节和调节缺氧的适应性反应。在许多肿瘤类型中，RHOBTB3 水平降低，被认为是一种肿瘤抑制因子，尽管尚未报道致病突变。
英文描述
Tolerance by Mtb to nitric oxide produced by macrophages Reactive nitrogen species (RNS), like reactive oxygen species, have numerous target molecules in the bacterial cell, and Mtb has developed remedies to the most important ones of them. This is a key reason for its ability to stay alive in the hostile environment of the late phagosome within human macrophages.
Mtb repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004).
Mtb repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004).
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