MET 激活 PTPN11
中文名称
通路描述
PTPN11 (SHP2) 通过 GAB1 被招募至激活的 MET 受体，并在 HGF 处理下发生磷酸化。虽然磷酸化位点和直接 MET 参与尚未被检查，但 PTPN11 对 HGF 处理的响应性磷酸化对于招募和激活 SPHK1 是必需的，这可能参与 HGF 诱导的细胞散射。同时，PTPN11 可在 MET 下游促进 MAPK3/1 (ERK1/2) 信号通路，也可在未鉴定的酪氨酸残基上脱磷酸化 MET。
英文描述
Cell redox homeostasis The most important response of Mtb to oxidative stress is provided by catalase and peroxiredoxins, both of which get their reducing equivalents through a network of disulfide proteins and, finally, from NAD(P)H. Multiple redundancies make choosing a good drug target difficult (Koul et al. 2011). Optimum efficacy can only be expected from inhibitors of the most upstream components of the redox cascades, i.e. the NAD(P)H-dependent reductases TrxB and Lpd (Jaeger & Flohe 2006).
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