颗粒外源性抗原的跨呈递
中文名称
通路描述
树突状细胞摄取和处理颗粒状外源性抗原，如微生物或肿瘤细胞，以进行 MHC-I 跨呈递。颗粒状抗原比可溶性抗原更有效地被树突状细胞跨呈递。颗粒状抗原被吞噬体摄取。解释外源性颗粒状抗原通过 MHC-I 跨呈递机制的两个已建立模型是：胞质途径，其中内化抗原从吞噬体转移到胞质进行蛋白酶体降解；以及囊泡途径（Lin et al. 2008, Amigorena et al. 2010）。
英文描述
Cross-presentation of particulate exogenous antigens (phagosomes) Dendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be more efficiently cross-presented than soluble antigens by DCs (Khor et al. 2008). Particulate antigens are internalized by phagosomes. There are two established models that explain the mechanism by which exogenous particulate antigens are presented through MHC I; the cytosolic pathway where internalized antigens are somehow translocated from phagosomes into cytosol for proteasomal degradation and the vacuolar pathway (Lin et al. 2008, Amigorena et al. 2010).
所含基因
8 个基因