精子运动与趋化性
中文名称
通路描述
一系列受体信号通路可能调节精子与卵子之间的化学通讯，通过趋化作用引导进入卵子的精子。虽然已确认几种物质是精子趋化因子，但孕酮（P）似乎是人类精子最好的趋化因子候选者。离子通道通过调节精子在雌性生殖道中的成熟以及触发受精所需的关键精子生理反应（如超激活运动、趋化和顶体反应）来控制精子受精的能力。CatSper、一个受pH调节的钙选择性离子通道，以及钾通道KSper（Slo3），和Hv1，是电压门控质子通道，参与调节精子超激活运动。虽然由排卵的颗粒细胞分泌的孕酮可能在短距离内作为精子细胞的趋化因子，但哺乳动物雌性生殖道中长距离精子引导的主要决定因素是流趋化性。
英文描述
Sperm Motility And Taxes A series of receptor signaling pathways potentially govern chemical communication between sperm and egg, chemotactically guiding incoming sperm towards the oocyte. Though several substances are confirmed as sperm chemoattractant, progesterone (P) seems to be the best chemoattractant candidate for human sperm. Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in the female reproductive tract and by triggering key sperm physiological responses required for successful fertilization such as hyperactivated motility, chemotaxis, and the acrosome reaction. CatSper, a pH regulated, calcium selective ion channel, potassium channel KSper (Slo3), and Hv1, the voltage gated proton channel are involved in regulation of sperm hyperactivated motility. While progesterone, secreted by ovulated cumulus oophorus, may act as a chemoattractant for sperm cells over the short distances, a major determinant of sperm guidance over long distances in the mammalian female reproductive tract is rheotaxis.
所含基因
9 个基因