ERBB2信号通路中的GRB7事件
中文名称
通路描述
ERBB2和ERBB3异二聚体通过磷酸化酪氨酸残基在ERBB3的C尾（Y1199和Y1262）上结合GRB7（Fiddes et al. 1998），但该复合物的确切下游信号尚未阐明。GRB7可以招募SHC1到活跃的ERBB2复合体上，并促进ERBB2信号诱导的RAS激活，从而促进细胞增殖，但确切机制尚未阐明（Pradip et al. 2013）。此外，GRB7可通过整合素激活的PTK2（FAK）磷酸化，导致VAV2依赖性激活的RAC1和促进细胞迁移。GRB7诱导的RAC1激活的确切机制细节尚不清楚（Pradip et al. 2013）。
英文描述
GRB7 events in ERBB2 signaling Heterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262) (Fiddes et al. 1998), but the exact downstream signaling of this complex has not been elucidated. GRB7 can recruit SHC1 to the active ERBB2 complex, and contributes to ERBB2 signaling-induced RAS activation, which promotes cellular proliferation, but the exact mechanism has not been elucidated (Pradip et al. 2013). In addition, GRB7 can be phosphorylated by the integrin-activated PTK2 (FAK), leading to VAV2-dependent activation of RAC1 and promotion of cell migration. The exact mechanistic details of GRB7-induced RAC1 activation are not known (Pradip et al. 2013).
所含基因
4 个基因