betaKlotho介导的配体结合
中文名称
通路描述
FGF21和FGF19需要betaKlotho才能在FGFR1c和FGFR3c上发挥高效信号。betaKlotho不与'b'受体等位基因相互作用，且仅与FGFR2c弱相互作用。此外，FGF19但非FGF21通过betaKlotho依赖性方式在FGFR4上信号
英文描述
betaKlotho-mediated ligand binding FGF21 and FGF19 require betaKlotho for efficient signaling through FGFR1c and FGFR3c. betaKlotho does not interact with 'b' receptor isoforms, and only weakly with FGFR2c. In addition, FGF19, but not FGF21, signals through FGFR4 in a betaKlotho-dependent fashion
所含基因
3 个基因