BMAL1:CLOCK,NPAS2 激活昼夜节律表达
中文名称
通路描述
根据小鼠推断,BMAL1:CLOCK (ARNTL:CLOCK) 和 BMAL1:NPAS2 (ARNTL:NPAS2) 异二聚体结合靶基因启动子上的序列元件 (E 盒),并增强转录 (Gekakis et al. 1998, 综述在 Munoz and Baler 2003)。
英文描述
BMAL1:CLOCK,NPAS2 activates circadian expression As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).
所含基因
25 个基因