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BMAL1:CLOCK,NPAS2 activates circadian expression

Reactome ID: R-HSA-1368108

中文名称

BMAL1:CLOCK,NPAS2 激活昼夜节律表达

通路描述

根据小鼠推断,BMAL1:CLOCK (ARNTL:CLOCK) 和 BMAL1:NPAS2 (ARNTL:NPAS2) 异二聚体结合靶基因启动子上的序列元件 (E 盒),并增强转录 (Gekakis et al. 1998, 综述在 Munoz and Baler 2003)。
英文描述
BMAL1:CLOCK,NPAS2 activates circadian expression As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

所含基因

25 个基因