细胞内 Ca2+水平升高
中文名称
通路描述
非兴奋性细胞的激活涉及促激肽释放素诱导的细胞内 Ca2+升高，这是血小板激活所必需的过程。它通过细胞内储存的 Ca2+释放和通过细胞膜的 Ca2+进入而发生。Ca2+储存释放涉及磷脂酶 C (PLC)介导的肌醇 -1,4,5-三磷酸 (IP3)产生，后者进而刺激 IP3 受体通道从细胞内储存中释放 Ca2+。随后，Ca2+通过细胞膜钙通道进入细胞，这一过程称为储存依赖性钙内流 (SOCE)。基质相互作用分子 1 (STIM1)是细胞内储存中的 Ca2+传感器分子，而四跨膜通道蛋白 Orai1 是血小板 SOCE 的关键参与者。其他主要的 Ca2+进入机制由直接受体介导的钙 (ROC)通道、P2X1和瞬时受体电位通道 (TRPCs)介导。
英文描述
Elevation of cytosolic Ca2+ levels Activation of non- excitable cells involves the agonist-induced elevation of cytosolic Ca2+, an essential process for platelet activation. It occurs through Ca2+ release from intracellular stores and Ca2+ entry through the plasma membrane. Ca2+ store release involves phospholipase C (PLC)-mediated production of inositol-1,4,5-trisphosphate (IP3), which in turn stimulates IP3 receptor channels to release Ca2+ from intracellular stores. This is followed by Ca2+ entry into the cell through plasma membrane calcium channels, a process referred to as store-operated calcium entry (SOCE). Stromal interaction molecule 1 (STIM1), a Ca2+ sensor molecule in intracellular stores, and the four transmembrane channel protein Orai1 are the key players in platelet SOCE. Other major Ca2+ entry mechanisms are mediated by the direct receptor-operated calcium (ROC) channel, P2X1 and transient receptor potential channels (TRPCs).
所含基因
16 个基因