通过 MAD2 抑制信号放大未附着动粒的信号

中文名称

通路描述

未附着动粒的信号通过 MAD2 抑制信号进行放大。该信号通过 Mad1 与动粒的结合、Mad2 与 Mad1 的结合、Mad2 与 Mad1 结合后构象转化为抑制形式以及 Mad2 抑制形式从动粒释放，从而被放大。

英文描述

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal The signal from unattached kinetochores is amplified through a Mad2 inhibitory signal that is propagated by the binding of Mad1 to the kinetochore, the association of Mad2 with Mad1, the conversion of Mad2 conformation to an inhibitory form through its association with Mad1 and finally the release of the inhibitory form of Mad2 from the kinetochore.

所含基因

92 个基因

AHCTF1 APITD1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CDC20 CDCA8 CENPA CENPC1 CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CKAP5 CLASP1 CLASP2 CLIP1 DSN1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L INCENP ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 MLF1IP NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 PAFAH1B1 PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RANBP2 RANGAP1 RCC2 RPS27 SEC13 SGOL1 SGOL2 SKA1 SKA2 SPC24 SPC25 SPDL1 TAOK1 XPO1 ZW10 ZWILCH ZWINT