二酰基甘油和甘油三酯酰基链重排
中文名称
通路描述
二酰基甘油（DAG）和甘油三酯（TAG）的酰基链重排通过 patatin-like 磷脂酶结构域蛋白 2/3（PNPLA2/3）的水解进行。DAG 由酰甘油 O-酰基转移酶 1/2（DGAT1/2）重新酰基化为 TAG，而 DAG 及其水解产物 2-单酰甘油（2-MAG）则由 PNPLA2/3 转酰基化为 TAG。此外，DAG 水解产物 2-MAG 随后由单酰甘油脂肪酶（MGLL）水解为脂肪酸和甘油（Jenkins 等，2004）。
英文描述
Acyl chain remodeling of DAG and TAG Acyl chain remodeling of triacylglycerol (TAG) and diacylglycerol (DAG) progresses through their hydrolysis by patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3). DAG is reacylated back to TAG by acylglycerol O-acyltransferase 1/2 (DGAT1/2), while DAG and its hydrolysis product 2-monoacylglycerol (2-MAG) are transacylated back to TAG by PNPLA2/3. In addition, the DAG hydrolysis product 2-MAG is subsequently hydrolyzed to fatty acid and glycerol by monoglyceride lipase (MGLL) (Jenkins et al. 2004).
所含基因
7 个基因