PA 的合成
中文名称
通路描述
在磷脂酸（PA）的从头合成过程中，磷脂酰肌醇（LPA）最初由甘油 3-磷酸酰转移酶（GPAT）将甘油 3-磷酸（G3P）酯化形成。随后，LPA 由磷脂酰肌醇酰转移酶（AGPAT，也称为 LPAAT）转化为 PA。此外，PA 还通过磷脂酶 D1 和 D2（PLD1 和 2）水解磷脂酰胆碱（PC）形成。PA 还通过磷脂酶裂解后由酰基转移酶重新酰基化参与酰基链重塑（Ghomashchi 等 2010，Singer 等 2002，Prasad 等 2011，Shindou 和 Shimizu 2009，Cao 等 2006）。
英文描述
Synthesis of PA In the de novo synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of sn-1 by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosphate (G3P). Next, LPA is converted to PA by a LPA acyltransferase (AGPAT, also known as LPAAT). In addition to this, PA is also formed when phosphatidylcholine (PC) is hydrolyzed by phospholipases D1 and D2 (PLD1 and 2). PA is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by acyltransferases (Ghomashchi et al. 2010, Singer et al. 2002, Prasad et al. 2011, Shindou & Shimizu 2009, Cao et al. 2006).
所含基因
39 个基因