ER 和 Golgi 膜之间 PI 和 PC 的运输
中文名称
通路描述
磷脂酰肌醇转移蛋白β等位基因（PITPNB）与磷脂酰肌醇（PI）复合物结合，从内质网（ER）膜运输到高尔基体膜，在那里磷脂酰胆碱（PC）与 PI 交换。PITPNB 现在与 PC 复合物结合，返回 ER 膜，现在 PI 与 PC 交换，循环重复。该过程已在牛和啮齿动物模型系统中得到详细表征（例如，Wirtz 等 2006；Ghosh 和 Bankaitis 2011），为组织更有限的关于高度保守的人类蛋白质和过程的可用数据提供了框架（Carvou 等 2010，Shadan 等 2008）。
英文描述
PI and PC transport between ER and Golgi membranes The phosphatidylinositol transfer protein beta isoform (PITPNB) bound to phosphatidylinositol (PI) complex transports from the endoplasmic reticulum (ER) membrane to the Golgi membrane, where phosphatidylcholine (PC) is exchanged for PI. PITPNB now in complex with PC transports back to the ER membrane where PI is now exchanged for PC, and the cycle repeats. This process has been characterized in detail in bovine and rodent model systems (e.g., Wirtz et al. 2006; Ghosh and Bankaitis 2011), which provide a framework for organizing the more limited data available for the very well conserved human proteins and processes( Carvou et al. 2010, Shadan et al. 2008).
所含基因
1 个基因