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Synthesis of PE

Reactome ID: R-HSA-1483213

中文名称

PE 的合成

通路描述

从头(Kennedy 途径)合成的磷脂酰乙醇胺(PE)涉及将乙醇胺(ETA)磷酸化为磷酸乙醇胺(PETA),随后与胞苷三磷酸(CTP)结合形成 CDP-乙醇胺(CDP-ETA)。二酰甘油(DAG)和 CDP-乙醇胺(CDP-ETA)随后形成 PE。或者,PE 也可以通过磷脂酰丝氨酸(PS)由磷脂酰丝氨酸脱羧酶前体(PISD)脱羧形成(Henneberry 等 2002,Vance 1991,Vance 1990)。
英文描述
Synthesis of PE De novo (Kennedy pathway) synthesis of phosphatidylethanolamine (PE) involves phosphorylation of ethanolamine (ETA) to phosphoethanolamine (PETA) followed by condensing with cytidine triphosphate (CTP) to form CDP-ethanolamine (CDP-ETA). Diacylglycerol (DAG) and CDP-ETA together then form PE. Alternatively, PE is formed when phosphatidylserine (PS) is decarboxylated by phosphatidylserine decarboxylase proenzyme (PISD) (Henneberry et al. 2002, Vance 1991, Vance 1990).

所含基因

13 个基因