γ-羧基化蛋白氨基末端前肽的去除
中文名称
通路描述
Furin 是一种定位于高尔基体膜的内肽酶，可切割序列 motif Arg-[任意残基]-（Lys 或 Arg）-Arg 羧基侧的许多蛋白。在γ-羧基化蛋白中，如果该切割不发生，蛋白仍被分泌但功能异常（Bristol 等 1993; Lind 等 1997; Wasley 等 1993）。该反应产生的氨基末端片段称为“前肽”，已知无功能；羧基化、切割后的蛋白被递送至细胞膜或从细胞分泌。
英文描述
Removal of aminoterminal propeptides from gamma-carboxylated proteins Furin is an endopeptidase localized to the Golgi membrane that cleaves many proteins on the carboxyterminal side of the sequence motif Arg-[any residue]-(Lys or Arg)-Arg (Jones et al. 1995; Leduc et al. 1992). In the case of gamma-carboxylated proteins, if this cleavage does not occur, the proteins are still secreted but do not function properly (Bristol et al. 1993; Lind et al. 1997; Wasley et al. 1993). The aminoterminal fragments, "propeptides", generated in this reaction have no known function; the carboxylated, cleaved proteins are delivered to the cell membrane or secreted from the cell.
所含基因
9 个基因