ZBP1(DAI)介导的I型干扰素诱导
中文名称
通路描述
ZBP1（也称为 DNA 依赖性干扰素调节因子 DAI）被报道在经多种外源 DNA 刺激后启动小鼠 L929 细胞的先天免疫反应（Takaoka A 等 2007）。人类巨细胞病毒（HCMV）被证明刺激人包皮 ZBP1 介导的 IRF3 诱导（DeFilippis VR 等 2010）。ZBP1 还涉及人胚胎肾 HEK293T 细胞中 NF-κB 通路的激活（Kaiser WJ 等 2008, Rebsamen M 等 2009）。然而，ZBP1 作为双链 DNA 传感器的作用和重要性仍存在争议，因为通过 siRNA 敲低 ZBP1 表达在其他人类或小鼠细胞类型中，对细胞质 DNA 的细胞反应影响很小，表明存在替代途径（Wang ZC 等 2008, Lippmann J 等 2008）。人类 ZBP1 的组织特异性表达表明 ZBP1 可能在细胞类型特异性方式中发挥作用（Rothenburg S 等 2002）。
英文描述
ZBP1(DAI) mediated induction of type I IFNs Z-DNA-binding protein-1 (ZBP1), also known as, DNA-dependent activator of IFN-regulatory factors (DAI) was reported to initiate innate immune responses in murine L929 cells upon stimulation by multiple types of exogenously added DNA (Takaoka A et al 2007). Human cytomegalovirus (HCMV) was shown to stimulate ZBP1-mediated induction of IRF3 in human foreskin (DeFilippis VR et al 2010). ZBP1 was also implicated in activation of NF-kappaB pathways in human embryonic kidney HEK293T cells (Kaiser WJ et al 2008, Rebsamen M et al 2009). However, the role and importance ofZBP1 as dsDNA sensor remain controversial, since knocking down ZBP1 expression in other human or murine cell types by siRNA had very little effect on cellular responses to cytosolic DNA, suggesting the presence of alternative pathway (Wang ZC et al 2008, Lippmann J et al 2008). Tissue-specific expression of human ZBP1 also suggests that ZBP1 may function in cell-type specific way (Rothenburg S et al 2002).
所含基因
1 个基因