IRF3介导的I型干扰素激活
中文名称
通路描述
干扰素调节因子（IRF）IRF-3 和 IRF-7 是响应病原分子调节 IFN 基因表达的主要调节因子。IRF3 和 IRF7 相对贡献取决于激活的信号通路。在细胞质 DNA 感应通路中，I 型干扰素的产生主要由 IRF3 介导，部分由 IRF7 介导，因为 DNA 刺激 IFN-β和 IFN-α4 mRNA 诱导在 IRF3 缺陷小鼠胚胎成纤维细胞（MEFs）中强烈抑制，而在 IRF7 缺陷 MEFs 中保持正常（IFN-β）或降低（IFN-α4）（Takaoke A 等 2007）。IRF3 对 B-DNA 刺激的响应通过其共招募与 TBK1 或诱导型 IκB 激酶（IKKi/IKKεpsilon）到 DAI 的 C 端区域发生。
英文描述
IRF3 mediated activation of type 1 IFN Interferon regulatory factors (IRF) IRF-3 and IRF-7 are the major modulators of IFN gene expression in response to pathogenic molecules. The relative contribution of IRF3 and IRF7 depends on the signaling pathway that is activated. Type I IFN production in cytosolic DNA-sensing pathway is mediated predominantly by IRF3 and partially by IRF7, since DNA-stimulated IFN-beta and IFN-alpha4 mRNA induction was strongly inhibited in IRF3-deficient mouse embryonic fibroblasts (MEFs), while remained normal (IFN-beta) or reduced (IFN-alpha4) in IRF7-deficient MEFs (Takaoke A et al 2007). IRF3 activation in response to B-DNA stimulation occurs via its co-recruitment with serine/threonine kinase TANK-binding kinase 1 (TBK1) or inducible IkB kinase (IKKi/IKKepsilon) to the C-terminal region of DAI.
所含基因
5 个基因