HIV 包膜的解包
中文名称
通路描述
HIV-1 解包是一个不太清楚的过程。它可能涉及基质和衣壳层的渐进性和部分解离。虽然像 MA 和 Nef 这样的病毒蛋白被认为参与其中，但主要的原因似乎是细胞质 pH 值和简单的稀释效应。成功的解包产生逆转录病毒复合物，该复合物包括二倍体病毒 RNA 基因组、tRNALys 引物、RT、IN、MA、核衣壳（NC）、病毒蛋白 R（Vpr）和各种宿主蛋白；因此，逆转录复合物从质膜中释放出来。被认为行进中的病毒核蛋白复合物与细胞骨架如微丝结合。
英文描述
Uncoating of the HIV Virion HIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, the primary cause seems to be the cytosolic pH and a simple dilution effect. Successful uncoating generates the viral reverse transcription complex, which comprises the diploid viral RNA genome, tRNALys primer, RT, IN, MA, nucleocapsid (NC), viral protein R (Vpr) and various host proteins; the reverse-transcription complex is thus liberated from the plasma membrane. It is believed that the transiting viral nucleoprotein complex associates with the elements of cytoskeleton like actin microfilaments.
所含基因
2 个基因