HIV 包膜的形成和成熟
中文名称
通路描述
当病毒成分在质膜内叶上精妙组装时，宿主细胞机器是必需的，以进行病毒出芽。病毒利用宿主 ESCRT 途径来终止 Gag 聚合并催化释放。ESCRT 途径通常负责膜分裂，产生充满细胞质的囊泡。在这种情况下，HIV（和其他病毒）利用 ESCRT 细胞机器来促进病毒从宿主细胞出芽。
英文描述
Budding and maturation of HIV virion With the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathway to terminate Gag polymerization and catalyze release. The ESCRT pathway is normally responsible for membrane fission that creates cytoplasm filled vesicular bodies. In this case HIV (and other viruses) take advantage of the ESCRT cellular machinery to facilitate virion budding from the host.
所含基因
30 个基因