mRNA 剪接 - 次要通路
中文名称
通路描述
某些前体 mRNA 内含子的剪接通过另一条途径进行，称为 AT-AC 或 U12 依赖性剪接途径。AT-AC 内含子具有高度保守的非经典剪接位点，由 AT-AC 剪接体去除，该剪接体包含与主要剪接体结构和功能相似的 snRNA（U11、U12、U4atac、U6atac）。U5 snRNA 以及许多蛋白质因子似乎在这两种剪接体之间是保守的。
英文描述
PKA-mediated phosphorylation of key metabolic factors Upon dissociation of protein kinase A (PKA) tetramers in the presence of cAMP, the released PKA catalytic monomers phosphorylate specific serine and threonine residues of several metabolic enzymes. These target enzymes include glycogen phosphorylase kinase, glycogen synthase and PF2K-Pase. PKA also phosphorylates ChREBP (Carbohydrate Response Element Binding Protein), preventing its movement into the nucleus and thus its function as a positive transcription factor for genes involved in glycolytic and lipogenic reactions.
所含基因
5 个基因