PKA 激活
中文名称
通路描述
许多无活性的四聚体PKA全酶是由不同调节亚基组成的同源或异源二聚体与两个催化亚基组合而产生的。当cAMP与调节亚基上的两个特定结合位点结合时，这些亚基发生构象变化，导致与四个cAMP结合的调节亚基二聚体与两个单体、具有催化活性的PKA亚基解离。
英文描述
PKA activation A number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds to two specific binding sites on the regulatory subunits, these undergo a conformational change that causes the dissociation of a dimer of regulatory subunits bound to four cAMP from two monomeric, catalytically active PKA subunits.
所含基因
18 个基因