胰岛素增加Xylose-5-磷酸的合成
中文名称
通路描述
胰岛素的一个下游效应是通过蛋白磷酸酶2A（PP2A）介导的，即增加Fructose-2,6-bisphosphate（果糖-2,6-二磷酸）的合成，它是磷酸果糖激酶1（PFK1）的变构激活剂。PFK1随后催化糖酵解的限速步骤，因此胰岛素启动的这一系列事件的净效应是增加细胞内糖酵解过程中形成的小分子的浓度。这反过来驱动了Xylose-5-磷酸（Xylose-5-磷酸）的合成，它本身是PP2A的正向调节剂。
英文描述
Insulin effects increased synthesis of Xylulose-5-Phosphate One of the downstream effects of insulin, mediated via protein phosphatase 2A (PP2A), is increased synthesis of Fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase 1 (PFK1). PFK1 in turn catalyzes the committed step of glycolysis so the net effect of this whole sequence of events set off by insulin is to increase cytosolic concentrations of the small molecules formed in the course of glycolysis. This in turn drives the increased synthesis of Xylulose-5-phosphate, itself a positive regulator of PP2A.
所含基因
2 个基因