ChREBP激活代谢基因表达
中文名称
通路描述
ChREBP（碳水化合物反应元件结合蛋白）是一种大型多结构域蛋白，其N端含有核定位信号，包含多脯氨酸结构域、一个碱性螺旋-环-螺旋-锌指结构域和一个锌指结构域（Uyeda等人，2002）。在分子信号与饱食状态相关的脱磷酸化后，它进入细胞核，与MLX蛋白结合，并结合乙酰辅酶A羧化酶、脂肪酸合酶和丙酮酸激酶（L等位基因）基因附近的ChRE DNA序列元件（Ishi等人，2004）。这一系列事件在下面的示意图中概括（改编自Kawaguchi等人（2001）-版权（2001）美国国家科学院）。
英文描述
ChREBP activates metabolic gene expression ChREBP (Carbohydrate Response Element Binding Protein) is a large multidomain protein containing a nuclear localization signal near its amino terminus, polyproline domains, a basic helix-loop-helix-leucine zipper domain, and a leucine-zipper-like domain (Uyeda et al., 2002). Its dephosphorylation in response to molecular signals associated with the well-fed state allows it to enter the nucleus, interact with MLX protein, and bind to ChRE DNA sequence motifs near Acetyl-CoA carboxylase, Fatty acid synthase, and Pyruvate kinase (L isoform) genes (Ishi et al.2004). This sequence of events is outlined schematically in the picture below (adapted from Kawaguchi et al. (2001) - copyright (2001) National Academy of Sciences, U.S.A.).
所含基因
8 个基因