PP2A介导的关键代谢因子的脱磷酸化
中文名称
通路描述
PP2A家族磷酸酶的一个成员脱磷酸化细胞质和核型ChREBP（碳水化合物反应元件结合蛋白）。在细胞核中，脱磷酸化的ChREBP与MLX蛋白结合，并结合到染色质DNA上的ChRE序列元件，激活参与糖酵解和脂生途径的基因的转录。该磷酸酶由Xylose-5-磷酸（Xylose-5-磷酸）激活，它是戊糖磷酸途径的中间产物（Kabashima等人2003）。大鼠酶已纯化至均一状态，并通过部分氨基酸序列分析显示与先前描述的PP2A磷酸酶不同（Nishimura和Uyeda 1995）-人类酶尚未表征。
英文描述
PP2A-mediated dephosphorylation of key metabolic factors A member of the PP2A family of phosphatases dephosphorylates both cytosolic and nuclear forms of ChREBP (Carbohydrate Response Element Binding Protein). In the nucleus, dephosphorylated ChREBP complexes with MLX protein and binds to ChRE sequence elements in chromosomal DNA, activating transcription of genes involved in glycolysis and lipogenesis. The phosphatase is activated by Xylulose-5-phosphate, an intermediate of the pentose phosphate pathway (Kabashima et al. 2003). The rat enzyme has been purified to homogeneity and shown by partial amino acid sequence analysis to differ from previously described PP2A phosphatases (Nishimura and Uyeda 1995) - the human enzyme has not been characterized.
所含基因
7 个基因