γ-羧基化、羟脯氨酸化、羟基化及阿拉伯糖苷酶激活
中文名称
通路描述
翻译后，许多新合成的蛋白质会经历进一步的共价修饰，从而改变其功能特性，且在生理条件下这些修饰基本上是不可逆的。这些修饰包括维生素 K 依赖性将羧基连接到谷氨酸残基以及将 eIF5A 中的赖氨酸残基转化为羟脯氨酸，将 EEF 中的组氨酸残基转化为二磷酸酰胺，以及多种氨基酸侧链的羟基化。
英文描述
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the vitamin K-dependent attachment of carboxyl groups to glutamate residues and the conversion of a lysine residue in eIF5A to hypusine, the conversion of a histidine residue in EEF to diphthamide, and the hydrxylation of various amino acid side chains.
所含基因
5 个基因