胰升糖素信号中的 PKA 激活
中文名称
通路描述
腺苷酸环化酶催化 ATP 合成环磷酸腺苷（cAMP）。在缺乏 cAMP 的情况下，蛋白激酶 A（PKA）以无活性的四聚体形式存在，该四聚体由两个催化亚基和两个调节亚基组成。cAMP 与 PKA 四聚体结合导致其解离并释放其催化亚基作为活性单体。已知的四种调节亚基异构体在组织特异性和功能特性上有所不同，但尚未确定在胰升糖素信号中激活的具体亚型。
英文描述
PKA activation in glucagon signalling Adenylate cyclase catalyses the synthesis of cyclic AMP (cAMP) from ATP. In the absence of cAMP, protein kinase A (PKA) exists as inactive tetramers of two catalytic subunits and two regulatory subunits. cAMP binding to PKA tetramers causes them to dissociate and release their catalytic subunits as active monomers. Four isoforms of the regulatory subunit are known, that differ in their tissue specificity and functional characteristics, but the specific isoform activated in response to glucagon signaling has not yet been identified.
所含基因
18 个基因