2-LTR 环的形成
中文名称
通路描述
2-LTR 环的形成需要细胞内非同源末端连接（NHEJ）途径的作用。具体需要细胞 Ku、XRCC4 和连接酶 IV 蛋白。证据表明，在这些功能发生缺陷的细胞中，无法检测到 2-LTR 环的形成，尽管整合和 1-LTR 环的形成主要正常。该反应发生在细胞核内，2-LTR 环的形成已被用作核运输的替代性检测。也有建议认为 NHEJ 系统影响逆转录病毒的毒性。
英文描述
2-LTR circle formation The formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this is provided by the observation that cells mutant in these functions do not support detectable formation of 2-LTR circles, though integration and formation of 1-LTR circles are mostly normal. The reaction takes place in the nucleus, and formation of 2-LTR circles has been used as a surrogate assay for nuclear transport. It has also been suggested that the NHEJ system affects the toxicity of retroviral infection.
所含基因
7 个基因