Nef 介导的 CD28 细胞表面表达下调
中文名称
通路描述
CD28 受体的下调涉及 Nef 的第二个无序环中的 dileucine 基序，该结构将 Nef 与细胞内吞机制中的适配蛋白复合物连接。Nef 通过夹心体凹陷加速 CD28 的内吞作用，随后在溶酶体中降解。
英文描述
Nef mediated downregulation of CD28 cell surface expression Down-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis machinery. Nef induces accelerated endocytosis of CD28 via clathrin-coated pits followed by lysosomal degradation.
所含基因
2 个基因