Nef 和信号转导
中文名称
通路描述
Nef 以多种方式干扰细胞信号转导途径。Nef 通过其 N 端泛酰化（myristoylation）和富含脯氨酸的 SH3 结合域与脂筏结合。这些富含胆固醇的膜微域似乎集中了强效的信号调节因子。Nef 被发现与并激活丝氨酸/苏氨酸蛋白激酶 PAK-2 结合，这可能有助于激活感染细胞。在体外，HIV 感染 T 细胞在激活时产生增强的白细胞介素 -2 水平。当在巨噬细胞中表达时，Nef 与 CD40L 信号转导途径相交，诱导分泌趋化因子和其他因子，吸引静止 T 细胞并促进其 HIV 感染。
英文描述
Nef and signal transduction Nef interferes with cellular signal transduction pathways in a number of ways. Nef is associated with lipid rafts through its amino-terminal myristoylation and a proline-rich SH3-binding domain. These cholesterol-rich membrane microdomains appear to concentrate potent signaling mediators. Nef was found to complex with and activate serine/threonine protein kinase PAK-2, which may contribute to activation of infected cells. In vitro, HIV-infected T cells produce enhanced levels of interleukin-2 during activation. When expressed in macrophages, Nef intersects the CD40L signaling pathway inducing secretion of chemokines and other factors that attract resting T cells and promote their infection by HIV.
所含基因
7 个基因