NFE2L2调节多药耐药相关酶
中文名称
通路描述
NFE2L2调节多药耐药相关酶子通路，代表由NFE2L2（NRF2）调控的多耐药基因。这些多耐药相关基因已知在药物耐药中发挥作用。例如，ABCF2在卵巢癌顺铂耐药中发挥作用（Bao et al, 2017）。同样，ABCC1（MRP1）、ABCC3和ABCG2也在多药耐药中发挥作用（Cole et al,2014; Zeng et al,1999; Mo et al, 2012）。
英文描述
Terminal pathway of complement After cleavage of C5, C5b undergoes conformational changes and exposes a binding site for C6. C5b6 binds C7 resulting in the exposure of membrane binding sites and incorporation into target membranes. The membrane-bound C5b-7 complex can then bind C8. C5b-8 acts as a polymerizing agent for C9. The first C9 bound to C5b-8 undergoes major structural changes enabling formation of an elongated molecule and allows binding of additional C9 molecules and insertion of C9 cylinders into the target membrane. The number of C9 molecules varies from 1-12 in the membrane, although polymers containing up to fifteen C9 molecules are also possible.
所含基因
7 个基因