PLC-gamma1信号
中文名称
通路描述
磷脂酶C-gamma（PLC-gamma）的激活以及随后从细胞内储存库中释放钙离子对于神经生长因子的分泌至关重要。PLC-gamma通过TrkA受体激酶的磷酸化而被激活，这种形式水解PIP2生成肌醇三磷酸（IP3）和双酰甘油（DAG）。IP3促进从内部储存库释放Ca2+，并导致蛋白激酶C和钙调蛋白依赖性蛋白激酶的激活。
英文描述
PLC-gamma1 signalling The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases.
所含基因
3 个基因