NGF加工
中文名称
通路描述
所有神经生长因子（NTs）都作为前神经生长因子前体生成。信号肽在NT与内质网（ER）结合时被切除。形成的前NT可以自发形成同源二聚体，然后转运至高尔基复合体，然后转运至跨高尔基网络（TGN）。驻留蛋白转化酶（PCs）可以切除前序列，成熟的NT被靶向到持续释放的囊泡。前NT形式也可以被释放到细胞外区域。
英文描述
NGF processing All neurotrophins (NTs) are generated as pre-pro-neurotrophin precursors. The signal peptide is cleaved off as NT is associated with the endoplasmic reticulum (ER). The resulting pro-NT can form a homodimer spontaneously which then transits to the Golgi apparatus and then onto the trans-Golgi network (TGN). Resident protein convertases (PCs) can cleave off the pro-sequence and mature NT is is targeted to constitutively released vesicles. The pro-NT form can also be released to the extracellular region.
所含基因
4 个基因