包含 HIV-1 Tat 的 HIV-1 延伸复合物的形成
中文名称
通路描述
该 HIV-1 事件是从 Reactome 中对应的人类 RNA Pol II 转录事件推断出来的。关于 HIV-1 的详细信息如下。HIV-1 延伸复合物的形成涉及 Tat 介导的 P-TEFb（Cyclin T1:Cdk9）招募到 TAR 序列（Wei et al, 1998）以及 P-TEFb（Cyclin T1:Cdk9）介导的 RNA Pol II CTD 磷酸化，以及负转录延伸因子 DSIF 和 NELF 的磷酸化（Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004）。
英文描述
Formation of HIV-1 elongation complex containing HIV-1 Tat This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).
所含基因
42 个基因