无Tat时HIV-1转录延伸的流产
中文名称
通路描述
该事件基于对应的人类Reactome Poll II转录延伸事件推断。HIV-1转录延伸的具体细节如下。在没有HIV-1 Tat蛋白的情况下，与HIV-1模板结合的RNA Pol II复合物是非进程性的。RNA Pol II在负转录延伸因子DSIF和NELF清除启动子后停滞，这与早期延伸内源性模板时的情况类似（Wada et al, 1998; Yamaguchi et al. 1999）。在没有Tat的情况下，P-TEFb介导的磷酸化无法克服这种停滞，导致延伸终止，产生短转录本（Kao et al., 1987）。
英文描述
Abortive elongation of HIV-1 transcript in the absence of Tat This event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of the HIV-1 Tat protein, the RNA Pol II complexes associated with the HIV-1 template are non-processive. RNA Pol II is arrested after promoter clearance by the negative transcriptional elongation factors DSIF and NELF as occurs during early elongation of endogenous templates (Wada et al, 1998; Yamaguchi et al. 1999). This arrest cannot be overcome by P-TEFb mediated phosphorylation in the absence of Tat however, and elongation aborts resulting in the accumulation of short transcripts (Kao et al., 1987).
所含基因
22 个基因