Nef 介导的 CD4 下调
中文名称
通路描述
Nef 的存在加速了膜糖蛋白 CD4 的内吞作用和溶酶体降解。CD4 具有其自身的内吞基序，但该基序通常被 CD4 与酪氨酸激酶 Lck 的结合所掩盖。Nef 已知会破坏这种相互作用，随后促进一系列蛋白相互作用，最终导致内吞 CD4 蛋白的降解。目前尚不清楚最终引导 Nef 至 COPI 共膜体β亚基的蛋白相互作用组。
英文描述
Nef Mediated CD4 Down-regulation The presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD4. CD4 has its own internalization motif, though this motif is normally concealed by CD4 interaction with Lck, a tyrosine kinase. Nef is known to disrupt this interaction and then facilitate a cascade of protein interactions that ultimately result in the degradation of internalized CD4 protein. The final set of protein interactions that direct Nef to the beta-subunit of the COPI coatomers are at this time unclear.
A benefit for the virus from CD4 down-modulation is abolition of interaction between the receptor and the Env protein of the budding virus, which likely increases HIV release from infected cell as well as infectivity of viral particles.
A benefit for the virus from CD4 down-modulation is abolition of interaction between the receptor and the Env protein of the budding virus, which likely increases HIV release from infected cell as well as infectivity of viral particles.
所含基因
9 个基因