Toll Like Receptor 3 (TLR3) 信号通路
中文名称
通路描述
Toll-like receptor 3 (TLR3) 在哺乳动物中表达于各种组织和细胞中，包括髓样树突状细胞、巨噬细胞、呼吸和肠道上皮、神经元和微胶质细胞，以诱导先天免疫的抗病毒和炎症反应，以对抗病毒感染。TLR3 在溶酶体中识别双链 RNA(dsRNA)，并触发受体二聚化。TLR3 招募接头蛋白 TRIF(TICAM1)，导致 NF-κB 激活和 I 型干扰素(IFNs)的产生。dsRNA 刺激下两个特定 TLR3 酪氨酸残基(Tyr759 和 Tyr858)的磷酸化对于启动 TLR3 信号通路至关重要。
英文描述
Toll Like Receptor 3 (TLR3) Cascade Toll-like receptor 3 (TLR3) as was shown for mammals is expressed in various tissues and cells, including myeloid dendritic cells, macrophages, respiratory and intestinal epithelium, neurons and microglial cells to induce antiviral and inflammatory responses of the innate immunity in combating viral infections.TLR3 recognizes dsRNA in the endosome and that triggers the receptor dimerization. TLR3 recruits the adaptor TRIF (TICAM1), leading to the activation of NF-kappa-B and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways.
所含基因
3 个基因