Toll Like Receptor 5 (TLR5) 信号通路
中文名称
通路描述
TLR5 是鞭毛蛋白(TLR5)的受体，该蛋白形成细菌鞭毛。与大多数其他病原体相关分子模式(PAMPs)不同，鞭毛蛋白没有经过任何翻译后修饰来区分它从细胞蛋白。然而，鞭毛蛋白在其氨基和羧基末端高度保守，这似乎解释了为什么它被选择为先天免疫识别的配体。TLR5 也表达于上皮细胞、巨噬细胞和树突状细胞中。肠道上皮中 TLR5 的表达是极化的，使得 TLR5 仅在细胞基底侧表达，因为致病但非共生微生物穿过上皮屏障。这确保了先天免疫反应局限于致病但非共生微生物（Paul 2004; Hayashi 等 2001; Gewirtz 等 2001）。
英文描述
Toll Like Receptor 5 (TLR5) Cascade TLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modifications that would distinguish it from cellular proteins. However, flagellin is extremely conserved at its amino- and carboxyl-termini, which presumably explains why it was selected as a ligand for innate immune recognition. TLR5 is expressed on epithelial cells as well as on macrophages and dendritic cells. Expression of TLR5 on intestinal epithelium is polarized such that TLR5 is expressed only on the basolateral side of the cell, as pathogenic but not commensal microbes cross the epithelial barrier. This ensures that innate immune responses are confined to pathogenic but not commensal microbes (Paul 2004; Hayashi et al. 2001; Gewirtz et al. 2001).
所含基因
1 个基因