Toll Like Receptor TLR1:TLR2 信号通路
中文名称
通路描述
TLR1 由单核表达。TLR1 和 TLR2 在细胞表面和细胞质中协同翻译形成异二聚体复合物。TLR2:TLR1 复合物识别 Neisseria 的 PorB 和结核分枝杆菌的三酰化脂蛋白和肽，以及其他物质，触发核因子κB(NF-κB)的产生上调和凋亡级联反应。例如，正常人外周血单核细胞上 TLR1 和 TLR2 之间的合作，导致促炎细胞因子分泌的激活（Sandor 等 2003）。
英文描述
Toll Like Receptor TLR1:TLR2 Cascade TLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial triacylated lipoproteins and peptides, amongst others, triggering up-regulation of nuclear factor-kappaB production and apoptotic cascades. Such cooperation between TLR1 and TLR2 on the cell surface of normal human peripheral blood mononuclear cells, for instance, leads to the activation of pro-inflammatory cytokine secretion (Sandor et al. 2003).
所含基因
6 个基因