Toll 样受体 TLR6:TLR2 级联
中文名称
通路描述
TLR2 和 TLR4 识别不同的细菌细胞壁成分。虽然 TLR4 被训练识别革兰氏阴性菌的脂多糖成分，但 TLR2 与 TLR6 结合在识别革兰氏阳性菌的肽聚糖壁产物以及 Mycobacterium 的酰化脂肽方面起着主要作用。特别是，TLR6 似乎参与区分双棕榈酰和三棕榈酰半胱氨酸残基之间的细微差异（Okusawa 等，2004）。
英文描述
Toll Like Receptor TLR6:TLR2 Cascade TLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recognizing peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides. In particular, TLR6 appears to participate in discriminating the subtle differences between dipalmitoyl and tripalmitoyl cysteinyl residues (Okusawa et al. 2004).
所含基因
3 个基因